Easy Synthesis and Characterization of Novel Carbon Dots Using the One-Pot Green Method for Cancer Therapy.

ABSTRACT: In this study, hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) were used for the synthesis of novel targeted nanocarrier carbon dots (CD_C-H) with photo-luminescence using a one-step hydrothermal method. Doxorubicin (DOX), a common chemotherapeutic agent, was loaded with the CD_C-H through electrostatic interactions to form DOX-CD_C-H complexes as a targeted antitumor drug delivery system. The synthesized CD_C-H show a particle size of approximately 6 nm and a high fluorescence quantum yield of 11.64%. The physical and chemical character properties of CD_C-H and DOX-CD_C-H complexes were investigated using various techniques. The results show that CD_C-H have stable luminescent properties and exhibit excellent wat

SUBMITTER: Wang L 

PROVIDER: S-EPMC9696114 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature