Standardized Pomegranate (Pomella^®) and Red Maple (Maplifa^®) Extracts and Their Phenolics Protect Type I Collagen by the Inhibition of Matrix Metalloproteinases, Collagenase, and Collagen Cross-Linking.

ABSTRACT: Phenolics enriched pomegranate fruit (Pomella^®) and red maple leaf (Maplifa^®) extracts and their major phenolic constituents have demonstrated beneficial skin effects through the protection of human skin keratinocytes from oxidative-stress-induced damage. However, their mechanisms of protection of cutaneous collagen are still unclear. Herein, the collagen protective effects of Pomella^® and Maplifa^®, and their major bioactive phytochemicals, namely, punicalagin (PA) and ginnalin A (GA), respectively, were evaluated using enzymatic assays including collagenase, anti-glycation and cell-based models as well as computational methods. The importance of the modulatory effects was validated at the protein level for type I collagen and matrix metalloprote

SUBMITTER: Li H 

PROVIDER: S-EPMC9696304 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature