Coronavirus disease 2019 vaccine effectiveness among a population-based cohort of people living with HIV.

ABSTRACT:

Objective

People with HIV were underrepresented in coronavirus disease 2019 (COVID-19) vaccine clinical trials. We estimated vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for the BNT162b2, mRNA-1273, and ChAdOx1 vaccines among a population-based cohort of people with HIV in Ontario, Canada.

Design

Test-negative design.

Methods

We identified people with HIV aged ≥19 years who were tested for SARS-CoV-2 by RT-PCR between December 14, 2020 (first availability of COVID-19 vaccines) and November 21, 2021 (pre-Omicron circulation). Outcomes included any infection, symptomatic infection, and COVID-19-related hospitalization/death. We compared the odds of vaccination between test-positive cases and test-negative cont

SUBMITTER: Chambers C 

PROVIDER: S-EPMC9696686 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature