Crystal Engineering of Ionic Cocrystals Sustained by Azolium···Azole Heterosynthons.

ABSTRACT: Crystal engineering of multi-component molecular crystals, cocrystals, is a subject of growing interest, thanks in part to the potential utility of pharmaceutical cocrystals as drug substances with improved properties. Whereas molecular cocrystals (MCCs) are quite well studied from a design perspective, ionic cocrystals (ICCs) remain relatively underexplored despite there being several recently FDA-approved drug products based upon ICCs. Successful cocrystal design strategies typically depend on strong and directional noncovalent interactions between coformers, as exemplified by hydrogen bonds. Understanding of the hierarchy of such interactions is key to successful outcomes in cocrystal design. We herein address the crystal engineering of ICCs comprising azole functional groups, particula

SUBMITTER: Rahmani M 

PROVIDER: S-EPMC9696709 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature