Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes.

ABSTRACT: The reaction of [Ru₂Cl₂(μ-Cl)₂(η⁶-p-cymene)₂] with two thiosemicarbazones obtained by the condensation of N-(4-methoxybenzyl) thiosemicarbazide and 1,4-hydroxy-3-methoxyphenyl)ethan-1-one (HL¹) or 2-fluoro-4-hydroxybenzaldehyde (HL²) was studied. The cationic complexes of formula [RuCl(η⁶-p-cymene)(HL)]⁺ were isolated as solid chloride and trifluoromethylsulfate (TfO) salts. A study of the solid state and NMR spectra suggests the presence in the material of two isomers that differ in the configuration in the iminic bond, C2=N3, of the coordinated thiosemicarbazone in the triflate salts and only the E isomer in the chloride. An X-ray study of single crystals

SUBMITTER: Martinez-Estevez M 

PROVIDER: S-EPMC9696800 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature