Genetic Addiction Risk and Psychological Profiling Analyses for "Preaddiction" Severity Index.

ABSTRACT: Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including genome-wide association studies (GWAS). To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum's group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. In order to statistically validate the selection of these risk alleles measured by GARS, we applied strict analysis to studies that investigated the association of each polymorphism with AUD or AUD-related conditions, including pain and even bariatric surgery, as a predictor of s

SUBMITTER: Blum K 

PROVIDER: S-EPMC9696872 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature