Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity.

ABSTRACT: Maintaining the excitability of neurons and circuits is fundamental for healthy brain functions. The global compensatory increase in excitatory synaptic strength, in response to decreased activity, is one of the main homeostatic mechanisms responsible for such regulation. This type of plasticity has been extensively characterized in rodents in vivo and in vitro, but few data exist on human neurons maturation. We have generated an in vitro cortical model system, based on differentiated human-induced pluripotent stem cells, chronically treated with tetrodotoxin, to investigate homeostatic plasticity at different developmental stages. Our findings highlight the presence of homeostatic plasticity in human cortical networks and show that the changes in synaptic strength are due to both pre- and

SUBMITTER: Cordella F 

PROVIDER: S-EPMC9696876 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature