Discovery of N-Containing (-)-Borneol Esters as Respiratory Syncytial Virus Fusion Inhibitors.

ABSTRACT: Respiratory syncytial virus (RSV) causes acute respiratory infections, thus, posing a serious threat to the health of infants, children, and elderly people. In this study, we have discovered a series of potent RSV entry inhibitors with the (-)-borneol scaffold. The active compounds 3b, 5a, 5c, 7b, 9c, 10b, 10c, and 14b were found to exhibit activity against RSV A strain A2 in HEp-2 cells. The most active substances, 3b (IC₅₀ = 8.9 μM, SI = 111) and 5a (IC₅₀ = 5.0 μM, SI = 83), displayed more potency than the known antiviral agent Ribavirin (IC₅₀ = 80.0 μM, SI = 50). Time-of-addition assay and temperature shift studies demonstrated that compounds 3b, 5a, and 6b inhibit

SUBMITTER: Sokolova AS 

PROVIDER: S-EPMC9697025 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature