Disentangling Clinical Profiles of Apathy in Behavioral Variant Frontotemporal Dementia.

ABSTRACT:

Background

Apathy is highly frequent in behavioral variant frontotemporal dementia (bvFTD). It is presumed to involve different pathophysiological mechanisms and neuroanatomical regions.

Objective

We explored the hypothesis that subgroups showing distinct profiles of apathy and distinct patterns of atrophy within frontal lobes could be disentangled in bvFTD.

Methods

Using data-driven clustering applied to 20 bvFTD patients, we isolated subgroups according to their profiles on the three subscales of the Dimensional Apathy Scale (DAS). We explored their apathy profiles and atrophy patterns. Apathy profiles were characterized through both subjective measures of apathy by questionnaires and measures including objective behavioral metrics. Atrophy patterns were obtained by

SUBMITTER: Godefroy V 

PROVIDER: S-EPMC9697059 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature