Evolutionary Divergence of Phosphorylation to Regulate Interactive Protein Networks in Lower and Higher Species.

ABSTRACT: The phosphorylation of proteins affects their functions in extensively documented circumstances. However, the role of phosphorylation in many interactive networks of proteins remains very elusive due to the experimental limits of exploring the transient interaction in a large complex of assembled proteins induced by stimulation. Previous studies have suggested that phosphorylation is a recent evolutionary process that differently regulates ortholog proteins in numerous lineages of living organisms to create new functions. Despite the fact that numerous phospho-proteins have been compared between species, little is known about the organization of the full phospho-proteome, the role of phosphorylation to orchestrate large interactive networks of proteins, and the intertwined phospho-landscap

SUBMITTER: Pasquier C 

PROVIDER: S-EPMC9697241 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature