Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis during <i>Opisthorchis felineus</i> Infection.

ABSTRACT: Chronic opisthorchiasis associated with Opisthorchis felineus infection is accompanied by severe fibrotic complications. It is of high practical significance to elucidate the mechanisms of hepatic fibrosis in chronic infection dynamics. The goal of the study is to investigate the temporal profile of key markers and the Jagged1/Notch signaling pathway in the implementation of fibrosis in a chronic O. felineus infection. For the first time, using histological methods and real-time PCR analysis, we demonstrated the activation of the Jagged1/Notch pathway in liver fibrogenesis, including the activation of the Hes1 and Hey1 target genes during experimental opisthorchiasis in Mesocricetus auratus. Cluster analysis followed by regression analysis of key markers

SUBMITTER: Kovner A 

PROVIDER: S-EPMC9697314 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature