The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer.

ABSTRACT: Ovarian cancer (OC) is the fifth leading cause of women's death from cancers. The high mortality rate is attributed to the late presence of the disease and the lack of modern diagnostic tools, including molecular biomarkers. Moreover, OC is a highly heterogeneous disease, which contributes to early treatment failure. Thus, exploring OC molecular mechanisms could significantly enhance our understanding of the disease and provide new treatment options. Chromatin remodeling complexes (CRCs) are ATP-dependent molecular machines responsible for chromatin reorganization and involved in many DNA-related processes, including transcriptional regulation, replication, and reparation. Dysregulation of chromatin remodeling machinery may be related to cancer development and chemoresistance in OC. Some f

SUBMITTER: Vaicekauskaite I 

PROVIDER: S-EPMC9697406 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature