Effects of Different Corticosteroid Doses in Elderly Unvaccinated Patients with Severe to Critical COVID-19.

ABSTRACT: SARS-CoV-2 infection can induce a broad range of clinical symptoms, and the most severe cases are characterized by an uncontrolled inflammatory response with the overproduction of proinflammatory cytokines. Elevated levels of C-reactive protein, interleukin-1B, and interleukin-6 have become key signatures of severe COVID-19. For this reason, the use of 6 mg of dexamethasone has become a standard of care, although this regime may not be optimal. Even though various glucocorticoid doses have been proposed, it is still unclear which dose should be used to prevent adverse effects while at the same time reducing the inflammatory response. Here, we compared two different doses of corticosteroids in 52 elderly hospitalized patients with severe to critical COVID-19 to assess efficacy and safety. W

SUBMITTER: Scialo F 

PROVIDER: S-EPMC9697502 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature