The Mechanism and Role of N⁶-Methyladenosine (m⁶A) Modification in Atherosclerosis and Atherosclerotic Diseases.

ABSTRACT: N⁶-methyladenosine (m⁶A) modification is a newly discovered regulatory mechanism in eukaryotes. As one of the most common epigenetic mechanisms, m⁶A's role in the development of atherosclerosis (AS) and atherosclerotic diseases (AD) has also received increasing attention. Herein, we elucidate the effect of m⁶A on major risk factors for AS, including lipid metabolism disorders, hypertension, and hyperglycemia. We also describe how m⁶A methylation contributes to endothelial cell injury, macrophage response, inflammation, and smooth muscle cell response in AS and AD. Subsequently, we illustrate the m⁶A-mediated aberrant biological role in the pathogenesis of AS and AD, and analyze the levels of m⁶A methylation

SUBMITTER: Tan Q 

PROVIDER: S-EPMC9697759 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature