The Effect of the Gallbladder Environment during Chronic Infection on Salmonella Persister Cell Formation.

ABSTRACT: Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). Around 3-5% of individuals infected become chronic carriers, with the gallbladder (GB) as the predominant site of persistence. Gallstones (GS) aid in the development and maintenance of GB carriage, serving as a substrate to which Salmonellae attach and form a biofilm. This biofilm matrix protects bacteria from the host immune system and environmental stress. This shielded environment is an ideal place for the development of persister cells, a transient phenotype of a subset of cells within a population that allows survival after antibiotic treatment. Persisters can also arise in response to harsh environments such as the GB. Here we investigate if GB conditions affect the number of persisters in a

SUBMITTER: Gonzalez JF 

PROVIDER: S-EPMC9698170 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature