Targeting DNA Topoisomerase II in Antifungal Chemotherapy.

ABSTRACT: Topoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a strong need to expand the range of therapeutic options. In this review paper, we discussed the usefulness of fungal topo II as a molecular target for new drug discovery. On the basis of previously published data, we described structural and biochemical differences between fungal and human enzymes as well as a molecular basis of differential sensitivity to known anticancer drugs targ

SUBMITTER: Kondaka K 

PROVIDER: S-EPMC9698242 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature