In Vivo Glutathione S-Transferases Superfamily Proteome Analysis: An Insight into Aedes albopictus Mosquitoes upon Acute Xenobiotic Challenges.

ABSTRACT: In this study, the induction of glutathione S-transferase (GST) enzymatic activities in Aedes albopictus under 24 h of xenobiotic challenges was investigated. From LCMS analysis, 23 GST isoforms were identified under Delta, Epsilon, Sigma, Zeta, Omega, and Iota classes, together with one GSTX1-1 isoform, in both treated and untreated samples. Using STRING 11.5, the functional enrichment network of Gene Ontology (GO) analysis, the identified peptides were found to be involved in the glutathione metabolic biological process (GO:0006749, p-value: 1.93 × 10^-29), and the molecular functions involved are due to glutathione transferase (GO:0016848, p-value: 2.92 × 10^-8) aside from carbon-halide lyase activity (GO:004364, p-value: 1.21 × 10^-31

SUBMITTER: Hamzah SN 

PROVIDER: S-EPMC9698486 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature