Pathophysiology and Therapeutic Approaches for Spinal Cord Injury.

ABSTRACT: Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic functions. Despite extensive research in the last decades, SCI continues to be a global health priority affecting thousands of individuals every year. The lack of effective therapeutic strategies for patients with SCI reflects its complex pathophysiology that leads to the point of no return in its function repair and regeneration capacity. Recently, however, several studies started to uncover the intricate network of mechanisms involved in SCI leading to the development of new therapeutic approaches. In this work, we present a detailed description of the physiology and anatomy of the spinal cord and the pathophysiology of SCI. Additionally, we provide an overview of different molecular strategies

SUBMITTER: Lima R 

PROVIDER: S-EPMC9698625 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature