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Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population.


ABSTRACT: As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

SUBMITTER: Quach HQ 

PROVIDER: S-EPMC9698789 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population.

Quach Huy Quang HQ   Ovsyannikova Inna G IG   Grill Diane E DE   Warner Nathaniel D ND   Poland Gregory A GA   Kennedy Richard B RB  

Vaccines 20221103 11


As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our f  ...[more]

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