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Constitutively Active Androgen Receptor in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading cause of cancer-related death globally. It is also a sexually dimorphic disease with a male predominance both in HCC and in its precursors, non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). The role of the androgen receptor (AR) in HCC has been well documented; however, AR-targeted therapies have failed to demonstrate efficacy in HCC. Building upon understandings of AR in prostate cancer (PCa), this review examines the role of AR in HCC, non-androgen-mediated mechanisms of induced AR expression, the existence of AR splice variants (AR-SV) in HCC and concludes by surveying current AR-targeted therapeutic approaches in PCa that show potential for efficacy in HCC in light of AR-SV expression.

SUBMITTER: Montgomery EJ

PROVIDER: S-EPMC9699340 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Constitutively Active Androgen Receptor in Hepatocellular Carcinoma.

Montgomery Emma J EJ Xing Enming E Campbell Moray J MJ Li Pui-Kai PK Blachly James S JS Tsung Allan A Coss Christopher C CC

International journal of molecular sciences 20221109 22

Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading cause of cancer-related death globally. It is also a sexually dimorphic disease with a male predominance both in HCC and in its precursors, non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). The role of the androgen receptor (AR) in HCC has been well documented; however, AR-targeted therapies have failed to demonstrate efficacy in HCC. Building upon understandings of AR in prostate c ...[more]

PMID: 36430245

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