Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population.

ABSTRACT:

Background

Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear.

Objectives

The purpose of this study is to report the variant spectrum in a Chinese cohort with suspected BrS and to analyze their distinct clinical and electrocardiographic features.

Methods

Patients with suspected BrS from Tongji Hospital between 2008 and 2021 were analyzed retrospectively.

Results

A total of 79 probands were included in this study. Patients with type 1 BrS electrocardiogram (ECG) had a prolonged QRS duration compared to patients with type 2/3 BrS ECG. Of them, 59 probands underwent genetic testing. Twenty

SUBMITTER: Wang LL 

PROVIDER: S-EPMC9699371 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature