Degradation of Polymer-Drug Conjugate Nanoparticles Based on Lactic and Itaconic Acid.

ABSTRACT: Tuberculosis (TB) is still a significant threat to human health. A promising solution is engineering nanoparticulate drug carriers to deliver anti-TB molecules. Itaconic acid (ITA) potentially has anti-TB activity; however, its incorporation in nanoparticles (NP) is challenging. Here we show an approach for preparing polymer-ITA conjugate NPs and a methodology for investigating the NP degradation and ITA release mechanism. The conjugate was synthesized by the two-directional growing of polylactic acid (PLA) chains, followed by capping their extremities with ITA. The poly(lactate)-itaconate PLA-ITA was then used to formulate NPs. The degradation and drug release processes of the polymer conjugate NPs were studied qualitatively and quantitatively. The molecular structures of released species

SUBMITTER: Vuong MDL 

PROVIDER: S-EPMC9699510 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature