Characterizing OPRM1 DNA methylation in prescription opioid users with chronic musculoskeletal pain.

ABSTRACT:

Introduction

Many patients with chronic pain use prescription opioids. Epigenetic modification of the μ-opioid receptor 1 (OPRM1) gene, which codes for the target protein of opioids, may influence vulnerability to opioid abuse and response to opioid pharmacotherapy, potentially affecting pain outcomes.

Objective

Our objective was to investigate associations of clinical and sociodemographic factors with OPRM1 DNA methylation in patients with chronic musculoskeletal pain on long-term prescription opioids.

Methods

Sociodemographic variables, survey data (Rapid Estimate of Adult Health Literacy in Medicine-Short Form, Functional Comorbidity Index [FCI], PROMIS 43v2.1 Profile, Opioid Risk Tool, and PROMIS Prescription Pain Medication Misuse), and saliva sampl

SUBMITTER: Sheikh S 

PROVIDER: S-EPMC9699511 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature