Leveraging Multiple Data Streams for Prioritization of Mixtures for Hazard Characterization.

ABSTRACT: There is a growing need to establish alternative approaches for mixture safety assessment of polycyclic aromatic hydrocarbons (PAHs). Due to limitations with current component-based approaches, and the lack of established methods for using whole mixtures, a promising alternative is to use sufficiently similar mixtures; although, an established framework is lacking. In this study, several approaches are explored to form sufficiently similar mixtures. Multiple data streams including environmental concentrations and empirically and predicted toxicity data for cancer and non-cancer endpoints were used to prioritize chemical components for mixture formations. Air samplers were analyzed for unsubstituted and alkylated PAHs. A synthetic mixture of identified PAHs was created (Creosote-Fire Mix).

SUBMITTER: Rivera BN 

PROVIDER: S-EPMC9699527 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature