Role of N⁶‑methyladenosine in the pathogenesis, diagnosis and treatment of pancreatic cancer (Review).

ABSTRACT: Pancreatic cancer (PC) ranks as the seventh leading cause of cancer‑associated mortality, and is predicted to become the third leading cause of cancer‑associated mortality by the year 2025. Although advanced modalities of diagnosis and treatment have been continuously emerging, the mortality rate (466,003) approximated to that of the morbidity rate (495,773) in 2020. N⁶‑methyladenosine (m⁶A) has been shown to be methylated on the sixth N atom of adenine in RNA, which occurs co‑transcriptionally and serves to regulate gene expression post‑transcriptionally. The discovery of m⁶A has heralded a new era in the scientific investigation of PC. In the present review article, the classical conception of m⁶A and emerging hypotheses regarding its role are

SUBMITTER: Ye T 

PROVIDER: S-EPMC9699722 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature