Multilevel data integration and molecular docking approach to systematically elucidate the underlying pharmacological mechanisms of Er-Zhi-Wan against hepatocellular carcinoma.

ABSTRACT: As a multicomponent, multitarget empirical therapy, traditional Chinese medicine (TCM) has been used clinically in Asia for thousands of years. Due to this unique feature, TCM therapy is considered a promising therapeutic strategy for the treatment of hepatocellular carcinoma (HCC). Er-Zhi-Wan (EZW), a well-known TCM formula containing two herbs, Fructus Ligustri Lucidi (FLL, Nü-Zhen-Zi) and Ecliptae Herba (EH, Mo-Han-Lian), is commonly used in clinical practice to prevent and treat liver diseases. Modern pharmacological studies have shown that both EH and FLL can inhibit HCC proliferation. However, the pharmacological mechanism, potential targets, and clinical value of EZW in inhibiting HCC have not been fully elucidated. We used multilevel databases (Gene Expression Omnibus

SUBMITTER: Zheng S 

PROVIDER: S-EPMC9699749 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature