In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia.

ABSTRACT:

Objectives

To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.

Materials and methods

We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.

Results

The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asi

SUBMITTER: Abavisani M 

PROVIDER: S-EPMC9699957 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature