Association of synovial expression of growth and differentiation factor 5 (GDF5) with radiographic severity of knee osteoarthritis.

ABSTRACT:

Objectives

The growth and differentiation factor 5 (GDF5) gene plays a significant role in facilitating chondrogenesis, and GDF5 polymorphism is a genetic factor contributing to osteoarthritis (OA). However, the role of GDF5 expression in the synovial membrane remains unclear. The aim of this study was to determine the expression of GDF5 in the synovium in patients with primary knee OA.

Materials and methods

Thirty patients scheduled for total knee arthroplasty were enrolled. Patients were grouped according to the Kellgren and Lawrence classification (KL) as grade 3 (15 patients) and grade 4 (15 patients). Synovial tissue was collected, and the GDF5 expression level was determined by real-time PCR. Ten synovial samples were randomly selected to evaluate the degree of synovit

SUBMITTER: Witoonpanich B 

PROVIDER: S-EPMC9699975 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature