Effect of Atorvastatin on Serial Changes in Coronary Physiology and Plaque Parameters.

ABSTRACT:

Background

The effects of statin on coronary physiology have not been well evaluated.

Objectives

The authors performed this prospective study to investigate changes in coronary flow indexes and plaque parameters, and their associations with atorvastatin therapy in patients with coronary artery disease (CAD).

Methods

Ninety-five patients with intermediate CAD who received atorvastatin therapy underwent comprehensive physiological assessments with fractional flow reserve (FFR), coronary flow reserve, index of microcirculatory resistance, and intravascular ultrasound at the index procedure, and underwent the same evaluations at 12-month follow-up. Optimal low-density lipoprotein cholesterol (LDL-C) was defined as LDL-C <70 mg/dL or ≥50% reduction from the baseline. The p

SUBMITTER: Lee CH 

PROVIDER: S-EPMC9700034 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature