Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration.

ABSTRACT: Mesenchymal stem cells are multipotent stem cells that reside in many human tissues and organs. Mesenchymal stem cells are widely used in experimental and clinical regenerative medicine due to their capability to transdifferentiate into various lineages. However, when transplanted, they lose part of their multipotency and immunomodulatory properties, and most of them die after injection into the damaged tissue. In this review, we discuss the potential utility of melatonin in preserving mesenchymal stem cells' survival and function after transplantation. Melatonin is a pleiotropic molecule regulating critical cell functions including apoptosis, endoplasmic reticulum stress, and autophagy. Melatonin is also synthesized in the mitochondria where it reduces oxidative stress, the opening of the

SUBMITTER: Luchetti F 

PROVIDER: S-EPMC9700085 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature