Genotype-guided model significantly improves accuracy of tacrolimus initial dosing after liver transplantation.

ABSTRACT:

Background

The initial dose of tacrolimus after liver transplantation (LT) is critical for rapidly achieving the steady state of the drug concentration, minimizing the potential adverse reactions and warranting long-term patient prognosis. We aimed to develop and validate a genotype-guided model for determining personalized initial dose of tacrolimus.

Methods

By combining pharmacokinetic modeling, pharmacogenomic analysis and multiple statistical methods, we developed a genotype-guided model to predict individualized tacrolimus initial dose after LT in the discovery (n = 150) and validation cohorts (n = 97) respectively. This model was further validated in a prospective, randomized and single-blind clinical trial from August, 2021 to February, 2022 (n = 40, ChiCTR2100050288)

SUBMITTER: Shi B 

PROVIDER: S-EPMC9700266 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature