The mechanisms of aluminum-induced immunotoxicity in chicks.

ABSTRACT: Aluminum (Al) is a ubiquitous environmental pollutant representing a significant global health hazard to human and animal health, including chicks. Al toxicity causes oxidative stress, leading to tissue injury, and consequently causes various diseases. NRF2 signaling is vital for protecting cells against oxidative stress. Nuclear xenobiotic receptors are activated by exogenous toxins, thereby inducing the transcription of cytochrome P450 enzyme systems (CYP450s) isoforms involved in xenobiotic metabolism and transport. However, little is known about Al-induced oxidative stress, nuclear xenobiotic receptors and fibrosis in chicks and the mechanisms involved. In this study, male chicks were treated with 0 mg/kg and 500 mg/kg Al₂(SO₄)₃ to evaluate the mechanis

SUBMITTER: Cao C 

PROVIDER: S-EPMC9700292 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature