Ocular Biodistribution of Once-Daily 0.6% Bilastine Eye Drops Reveals Highest Levels in Conjunctiva Up to 24 h Postadministration.

ABSTRACT: Purpose: Bilastine is a second-generation antihistamine that has been shown to be effective for treatment of allergic conjunctivitis. The objective of this study was to evaluate the pharmacokinetics (PKs) and biodistribution of 0.6% bilastine preservative-free eye drops. Methods: Bilastine was quantified in the conjunctiva, cornea, aqueous humor, vitreous humor, iris/ciliary body, retina/choroid, crystalline lens, and plasma, following a single topical administration to male Dutch-belted rabbits. Results: Concentrations of bilastine were highest in the conjunctiva [C_max: 2,545.04 ng/g, at 6 h postadministration; area under the concentration-time curve (AUC_t): 11,382.40 ng·h/g] and cornea (C_max: 609.11 ng/g, at 1 h p

SUBMITTER: Torrens I 

PROVIDER: S-EPMC9700334 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature