Unveiling the functional and evolutionary landscape of RNA editing in chicken using genomics and transcriptomics.

ABSTRACT: The evolutionary and functional features of RNA editing are well studied in mammals, cephalopods, and insects, but not in birds. Here, we integrated transcriptomic and whole-genomic analyses to exhaustively characterize the expansive repertoire of adenosine-to-inosine (A-to-I) RNA editing sites (RESs) in the chicken. In addition, we investigated the evolutionary status of the chicken editome as a potential mechanism of domestication. We detected the lowest editing level in the liver of chickens, compared to muscles in humans, and found higher editing activity and specificity in the brain than in non-neural tissues, consistent with the brain's functional complexity. To a certain extent, specific editing activity may account for the specific functions of tissues. Our results also revealed th

SUBMITTER: Wang YM 

PROVIDER: S-EPMC9700494 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature