Group B streptococci infection model shows decreased regulatory capacity of cord blood cells.

ABSTRACT:

Background

Sepsis is one of the leading causes of morbidity and mortality in the neonatal period. Compared to adults, neonates are more susceptible to infections, especially to systemic infections with Group B Streptococcus (GBS). Furthermore, neonates show defects in terminating inflammation. The immunological causes for the increased susceptibility to infection and the prolonged inflammatory response are still incompletely understood.

Methods

In the present study, we aimed to investigate the reaction of cord blood mononuclear cells (MNC) to stimulation with GBS in comparison to that of MNC from adult blood with focus on the proliferative response in an in vitro infection model with heat-inactivated GBS.

Results

We demonstrate that after stimulation with GBS the prol

SUBMITTER: Molnar K 

PROVIDER: S-EPMC9700511 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature