Clinical Validation of the Covariates Pharmacokinetic Model for Propofol in an Adult Population.

ABSTRACT:

Background and objective

Pharmacokinetic or pharmacokinetic-pharmacodynamic models have been instrumental in facilitating the clinical use of propofol in target-controlled infusion systems in anaesthetic practice. There has been debate over which model should be recommended for practice. The covariates model is an updated pharmacokinetic model for propofol. The aim of this study was to prospectively validate this model in an adult population.

Methods

Twenty-nine patients were included, with a range of ages to assess model performance in younger and older individuals. Subjects received propofol through a target-controlled infusion device programmed with the covariates model. Subjects were randomised to one of two increasing/decreasing regimes of propofol plasma target concent

SUBMITTER: Hawthorne C 

PROVIDER: S-EPMC9700536 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature