Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries.

ABSTRACT:

Introduction

Controlling the formation of blood and lymphatic vasculatures is crucial for engineered tissues. Although the lymphatic vessels originate from embryonic blood vessels, the two retain functional and physiological differences even as they develop in the vicinity of each other. This suggests that there is a previously unknown molecular mechanism by which blood (BECs) and lymphatic endothelial cells (LECs) recognize each other and coordinate to generate distinct capillary networks.

Methods

We utilized Matrigel and fibrin assays to determine how cord-like structures (CLS) can be controlled by altering LEC and BEC identity through podoplanin (PDPN) and folliculin (FLCN) expressions. We generated BEC ^ΔFLCN and LEC ^ΔPDPN

SUBMITTER: Jeong DP 

PROVIDER: S-EPMC9700554 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature