Metabolic changes during exclusive enteral nutrition in pediatric Crohn's disease patients.

ABSTRACT:

Background and aims

Exclusive enteral nutrition is recommended as a first-line treatment in active pediatric Crohn's Disease, but its mechanism of action is still not clear. We aimed to assess alterations in the metabolic profile of newly diagnosed pediatric Crohn's Disease patients before and during exclusive enteral nutrition therapy.

Methods

Plasma samples from 14 pediatric Crohn's Disease patients before and after 3-4 weeks on exclusive enteral nutrition were analyzed using mass spectrometry. T-test, fold change and orthogonal partial least squares discriminant analysis were used for mining significant features. Correlation analysis was performed between the annotated features and the weighted pediatric Crohn's disease activity index using Pearson r distance.

Results<

SUBMITTER: Marques JG 

PROVIDER: S-EPMC9700625 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature