Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34⁺ stromal cell subsets.

ABSTRACT: Gut-draining mesenteric lymph nodes (LN) provide the framework to shape intestinal adaptive immune responses. Based on the transcriptional signatures established by our previous work, the composition and immunomodulatory function of LN stromal cells (SC) vary according to location. Here, we describe the single-cell composition and development of the SC compartment within mesenteric LNs derived from postnatal to aged mice. We identify CD34⁺ SC and fibroblastic reticular stromal cell (FRC) progenitors as putative progenitors, both supplying the typical rapid postnatal mesenteric LN expansion. We further establish the location-specific chromatin accessibility and DNA methylation landscape of non-endothelial SCs and identify a microbiota-independent core epigenomic signature, showin

SUBMITTER: Pezoldt J 

PROVIDER: S-EPMC9700677 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature