Successful tracheal regeneration using biofabricated autologous analogues without artificial supports

ABSTRACT: Tracheas have a tubular structure consisting of cartilage rings continuously joined by a connective tissue membrane comprising a capillary network for tissue survival. Several tissue engineering efforts have been devoted to the design of scaffolds to produce complex structures. In this study, we successfully fabricated an artificial materials-free autologous tracheal analogue with engraftment ability by combining in vitro cell self-aggregation technique and in-body tissue architecture. The cartilage rings prepared by aggregating chondrocytes on designated culture grooves that induce cell self-aggregation were alternately connected to the connective tissues to form tubular tracheal analogues by subcutaneous embedding as in-body tissue architecture. The tracheal analogues allogeneically impl

SUBMITTER: Hiwatashi S 

PROVIDER: S-EPMC9700768 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature