Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications.

ABSTRACT: Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted site are overwhelming and palpable. Engineering nanomaterials to deliver biological molecules to exert desirable physiological changes, with minimized side effects and optimal dose, has revolutionized the next-generation therapy for several diseases. The rapid progress of nucleic acids as biopharmaceutics is going to alter the traditional pharmaceutics practices in modern medicine. However, enzymatic instability, large size, dense negative charge (hydrophilic for cell uptake), and unintentional adverse biological responses-such as prolongation of the blood coagulation and immune system activation-hamper the potential use of nucleic acids for therapeutic purposes. Moreover, the safe delivery of nucle

SUBMITTER: Sharma AR 

PROVIDER: S-EPMC9700905 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature