High mesothelin expression is correlated with non-squamous cell histology and poor survival in cervical cancer: a retrospective study

ABSTRACT:

Background

Mesothelin (MSLN) is a cell-surface glycoprotein found in various solid tumours. Cancer therapies targeting MSLN have been developed in recent years; however, the available information on MSLN expression in cervical cancer is limited. This study aimed to evaluate MSLN expression in various histological types of cervical cancer and examine its relationship with prognosis.

Methods

This retrospective study included patients with cervical cancer who underwent primary surgery between January 2000 and December 2020 at our institution. MSLN expression was evaluated by immunohistochemistry using clone SP74 and defined as positive if MSLN was expressed at any intensity. High MSLN expression was defined as an intensity of ≥ 2 + in ≥ 30% of tumour cells. The association b

SUBMITTER: Takamizawa S 

PROVIDER: S-EPMC9701073 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature