Ontology highlight
ABSTRACT:
SUBMITTER: Zhu F
PROVIDER: S-EPMC9701212 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Zhu Fang F Li Chao-Xing CX Wu Zhu-Lian ZL Cai Tian T Wen Wei W Guo Qi-Xiang QX
Nature communications 20221126 1
The combined catalytic systems derived from organocatalysts and transition metals exhibit powerful activation and stereoselective-control abilities in asymmetric catalysis. This work describes a highly efficient chiral aldehyde-nickel dual catalytic system and its application for the direct asymmetric α-propargylation reaction of amino acid esters with propargylic alcohol derivatives. Various structural diversity α,α-disubstituted non-proteinogenic α-amino acid esters are produced in good-to-exc ...[more]