High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders.

ABSTRACT: Multiple cancer types have limited targeted therapeutic options, in part due to incomplete understanding of the molecular processes underlying tumorigenesis and significant intra- and inter-tumor heterogeneity. Identification of novel molecular biomarkers stratifying cancer patients with different survival outcomes may provide new opportunities for target discovery and subsequent development of tailored therapies. Here, we applied the artificial intelligence-driven PandaOmics platform ( https://pandaomics.com/ ) to explore gene expression changes in rare DNA repair-deficient disorders and identify novel cancer targets. Our analysis revealed that CEP135, a scaffolding protein associated with early centriole biogenesis, is commonly downregulated in DNA repair diseases with high cancer predis

SUBMITTER: Mkrtchyan GV 

PROVIDER: S-EPMC9701218 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature