Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions.

ABSTRACT: During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes. We have recently demonstrated that the activation of platelets by breast cancer cells is accompanied by a massive release of PEVs, evidence that matches with the observation that breast cancer patients display increased levels of circulating PEVs. A core concept in PEVs biology is that their nature, composition and biological function are strongly influenced by the conditions that induced their release. In this study we have performed a comparative characterization of PEVs released by platelets upon activation with thrombin, a potent thrombotic stimulus, and upon exposure to the breast cancer cell l

SUBMITTER: Vismara M 

PROVIDER: S-EPMC9701234 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature