Anti-inflammatory effects of the prostaglandin D₂/prostaglandin DP1 receptor and lipocalin-type prostaglandin D₂ synthase/prostaglandin D₂ pathways in bacteria-induced bovine endometrial tissue.

ABSTRACT: Dairy cows often develop different degrees of endometritis after calving and this is attributed to pathogenic bacterial infections such as by Escherichia coli and Staphylococcus aureus. Infection of the bovine endometrium causes tissue damage and increases the expression of prostaglandin D₂ (PGD₂), which exerts anti-inflammatory effects on lung inflammation. However, the roles of PGD₂ and its DP1 receptor in endometritis in cows remain unclear. Here, we examined the anti-inflammatory roles of the lipocalin-type prostaglandin D₂ synthase (L-PGDS)/PGD₂ and DP1 receptor regulatory pathways in bovine endometritis. We evaluated the regulatory effects of PGD₂ on inflammation and tissue damage in E. coli- and S. aureus-infected bov

SUBMITTER: Wu J 

PROVIDER: S-EPMC9701374 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature