Unilateral acute lung injury in pig: a promising animal model.

ABSTRACT:

Background

Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key parameters characterizing ALI as defined by the American Thoracic Society (ATS). Thus, the use of unilateral ALI remained rare despite the innovative approach. Therefore, we developed a unilateral model of ALI and focused on the crucial parameters characterizing ALI. This model can serve for direct comparisons between the injured and intact lungs within single animals, thus, reducing the number of animals required for valid experimental conclusions.

Methods

We established the model in nine pigs, followed by an evaluation of key parameters in six pigs (main s

SUBMITTER: Geilen J 

PROVIDER: S-EPMC9701381 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature