Molecular markers of dihydroartemisinin-piperaquine resistance in northwestern Thailand.

ABSTRACT:

Background

Dihydroartemisinin-piperaquine (DHA-PPQ) combination therapy is the current first-line treatment for Plasmodium falciparum malaria in Thailand. Since its introduction in 2015, resistance to this drug combination has emerged in the eastern part of the Greater Mekong Subregion including the eastern part of Thailand near Cambodia. This study aimed to assess whether the resistance genotypes have arisen the western part of country.

Methods

Fifty-seven P. falciparum-infected blood samples were collected in Tak province of northwestern Thailand between 2013 and 2019. Resistance to DHA was examined through the single nucleotide polymorphisms (SNPs) of kelch13. PPQ resistance was examined through the copy number plasmepsin-2 and the SNPs of Pfcrt.

Results

Among the

SUBMITTER: Win KN 

PROVIDER: S-EPMC9701414 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature