Engineering tumor-specific catalytic nanosystem for NIR-II photothermal-augmented and synergistic starvation/chemodynamic nanotherapy.

ABSTRACT:

Background

As an emerging therapeutic modality, chemodynamic therapy (CDT), converting hydrogen peroxide (H₂O₂) into highly toxic reactive oxygen species (ROS), has been developed for tumor-specific therapy. However, the deficiency of endogenous H₂O₂ and high concentration of glutathione (GSH) in the tumor microenvironment (TME) weaken the CDT-based tumor-therapeutic efficacy. Herein, a photothermal-enhanced tumor-specific cascade catalytic nanosystem has been constructed on the basis of glucose oxidase (GOD)-functionalized molybdenum (Mo)-based polyoxometalate (POM) nanoclusters, termed as GOD@POMs.

Methods

GOD@POMs were synthesized by a facile one-pot procedure and covalently conjugation. Then, its structure was characterized by

SUBMITTER: Zhou S 

PROVIDER: S-EPMC9701438 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature