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Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years.

ABSTRACT: Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.

SUBMITTER: Durier C 

PROVIDER: S-EPMC9701678 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years.

Durier Christine C   Ninove Laetitia L   Lefebvre Maeva M   Radenne Anne A   Desaint Corinne C   Ropers Jacques J   Bauer Rebecca R   Lebbah Said S   Carette Diane D   Lachatre Marie M   Lecompte Anne-Sophie AS   Deplanque Dominique D   Botelho-Nevers Elisabeth E   Conrad Anne A   Dussol Bertrand B   Maakaroun-Vermesse Zoha Z   Melica Giovanna G   Nicolas Jean-François JF   Verdon Renaud R   Kiladjian Jacques J   Loubet Paul P   Schmidt-Mutter Catherine C   Dualé Christian C   Ansart Séverine S   Priet Stéphane S   Levier Axel A   Molino Diana D   Vieillard Louis-Victorien LV   Parfait Béatrice B   Lelièvre Jean-Daniel JD   Tartour Eric E   de Lamballerie Xavier X   Launay Odile O  

Scientific reports 20221127 1

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost. ...[more]

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